The purpose of this program is to determine how well a new tracer (a substance given during a brain PET scan) can help identify tau (a protein found in the brain of people with Alzheimer’s disease). In order to do this, comparisons are made between the brain PET scans of people with Alzheimer’s disease and those without.  After passing, comparisons are then made between the brain tissue of people who pass from Alzheimer’s disease vs other conditions.  The goal is to develop a tau-protein tracer that can help diagnose Alzheimer’s disease earlier so that potential preventative measures and treatments can be developed. This sponsored care program is for people in hospice or with a one-year or less life expectancy.  Participation involves one screening visit (either at Esperanza Clinical or at the patient’s home) and one brain PET scan (for which transportation may be provided), and then brain donation upon passing. The benefits include a $3,000 stipend that can help cover funeral costs, body transportation after passing, a detailed brain PET scan report and all clinical results from the exam, as well as the opportunity for participants to make an invaluable contribution to advancing AD research.

SERENADA is a sponsored care program designed for those with Alzheimer’s disease who are experiencing agitation and/or aggression. Examples of agitation may include restlessness, irritability, resistance to care, or difficulty remaining calm. Examples of aggression may include verbal outbursts, physical actions, or unsafe behaviors toward others or the environment. This program compares two doses of a study medicine and placebo for the management of these symptoms. Participation includes bi-weekly clinic visits to assess behavioral and cognitive functioning.  The program will last up to 14 weeks.

This is a sponsored care program designed for those experiencing delusions and hallucinations due to Alzheimer’s Disease. Examples of delusions may include fixed beliefs that are not based in reality and persist despite reassurance. Examples of hallucinations may include seeing, hearing, smelling, feeling, or tasting things that others do not perceive. The purpose of the program is to assess the safety and efficacy of ML-007C-MA, the investigational oral study medicine compared to placebo. Participation involves clinic visits, behavioral and cognitive assessments, and interviews with participants and their caregivers/support person to understand daily activities and quality of life. The duration of participation is seven visits total over 13 weeks.